E-AB-90163
RFTN1 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-90163
- Additional Names:
- MIG2,PIB10,PIG9,RAFTLIN,RFTN1,raftlin
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human RFTN1
- Uniprot:
- Q14699
- Synonyms:
- cell migration-inducing gene 2 protein;MIG2;PIB10;PIG9;proliferation-inducing protein 10;proliferation-inducing protein 9;raft-linking protein;raftlin
- Extra Details:
- Involved in protein trafficking via association with clathrin and AP2 complex. Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages, and internalization of poly(I:C to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion (By similarity. May regulate B-cell antigen receptor-mediated signaling. May play a pivotal role in the formation and/or maintenance of lipid rafts.
- Shipping Conditions:
- Blue Ice