E-AB-90009
Bcl10 Polyclonal Antibody
Size
£285.30
Was £317.00
- SKU:
- E-AB-90009
- Additional Names:
- BCL10,CARMEN,CIPER,CLAP,IMD37,c-E10,mE10
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human Bcl10
- Uniprot:
- O95999
- Synonyms:
- B cell CLL/lymphoma 10;B-cell CLL/lymphoma 10;B-cell lymphoma/leukemia 10;c-E10;CARD containing molecule enhancing NF-kB;CARD-containing apoptotic signaling protein;CARD-containing molecule enhancing NF-kappa-B;CARD-containing proapoptotic protein;CARD-like apoptotic protein;CARMEN;caspase-recruiting domain-containing protein;cCARMEN;CED-3/ICH-1 prodomain homologous E10-like regulator;cellular homolog of vCARMEN;cellular-E10;CIPER;CLAP;hCLAP;IMD37;mammalian CARD-containing adapter molecule E10;mE10
- Extra Details:
- This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.
- Shipping Conditions:
- Blue Ice