E-AB-81599
Recombinant Presenilin 1 Monoclonal Antibody
Size
£178.20
Was £198.00
- SKU:
- E-AB-81599
- Additional Names:
- AD3,FAD,PS-1,PS1,PSEN1,Presenilin 1,S182
- Application:
- WB
- Concentration:
- 300 ug/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% stabilizer and 0.05% protective protein.
- Immunogen:
- A synthetic peptide of human Presenilin 1
- Clone:
- R05-4D4
- Uniprot:
- P49768
- Synonyms:
- ACNINV3;AD3;FAD;presenilin-1;Protein S182;PS-1;PS1;S182
- Extra Details:
- Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.
- Shipping Conditions:
- Blue Ice