Recombinant PCBP2 Monoclonal Antibody

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£178.20

Was £198.00

SKU:: E-AB-81594
Additional Names:: HNRNPE2,HNRPE2,PCBP2,hnRNP-E2
Application:: WB
Concentration:: 300 ug/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Mouse, Rat
Buffer:: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% stabilizer and 0.05% protective protein.
Immunogen:: A synthetic peptide of human PCBP2
Clone:: R01-2F5
Uniprot:: Q15366
Synonyms:: alpha-CP2;epididymis secretory sperm binding protein;heterogeneous nuclear ribonucleoprotein E2;heterogenous nuclear ribonucleoprotein E2;hnRNP E2;hnRNP-E2;HNRNPE2;HNRPE2;poly(rC)-binding protein 2
Extra Details:: The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene.

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