Recombinant Bcr Monoclonal Antibody

Size

£178.20

Was £198.00

SKU:: E-AB-81535
Additional Names:: ALL,BCR1,Breakpoint cluster region,CML,D22S11,D22S662,PHL,Renal carcinoma antigen NY-REN-26,bcr
Application:: IHC, WB, IHC-P
Concentration:: 300 ug/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human
Buffer:: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% stabilizer and 0.05% protective protein.
Immunogen:: A synthetic peptide of human Bcr
Clone:: R02-6I0
Uniprot:: P11274
Synonyms:: ALL;BCR, RhoGEF and GTPase activating protein;BCR/FGFR1 chimera protein;BCR1;breakpoint cluster region;breakpoint cluster region protein;CML;D22S11;D22S662;FGFR1/BCR chimera protein;PHL;renal carcinoma antigen NY-REN-26
Extra Details:: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.