Recombinant SF3B1 Monoclonal Antibody

Size

£178.20

Was £198.00

SKU:: E-AB-81510
Additional Names:: Hsh155,MDS,PRP10,PRPF10,SAP155,SF3B1,SF3b155
Application:: IHC, WB, IHC-P
Concentration:: 300 ug/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Hamster, Human, Mouse
Buffer:: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% stabilizer and 0.05% protective protein.
Immunogen:: A synthetic peptide of human SF3B1
Clone:: R08-6I2
Uniprot:: O75533
Synonyms:: Hsh155;MDS;pre-mRNA processing 10;pre-mRNA splicing factor SF3b, 155 kDa subunit;Pre-mRNA-splicing factor SF3b 155 kDa subunit;PRP10;PRPF10;SAP155;SF3b155;spliceosome-associated protein 155;splicing factor 3B subunit 1;splicing factor 3b, subunit 1, 155kDa
Extra Details:: This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.