E-AB-81487
Recombinant Transcription Factor 7 Like 2 Monoclonal Antibody
Size
£178.20
Was £198.00
- SKU:
- E-AB-81487
- Additional Names:
- HMG box transcription factor 4,HTCF-4,T-cell factor 4,T-cell factor-4 variant X2,TCF-4,TCF7L2,Transcription factor 7-like 2
- Application:
- IHC, WB, IHC-P
- Concentration:
- 300 ug/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% stabilizer and 0.05% protective protein.
- Immunogen:
- A synthetic peptide of human TCF-4
- Clone:
- R09-1D1
- Uniprot:
- Q9NQB0
- Synonyms:
- HMG box transcription factor 4;hTCF-4;T-cell factor 4;T-cell-specific transcription factor 4;TCF-4;TCF4;transcription factor 7-like 2;transcription factor 7-like 2 (T-cell specific, HMG-box)
- Extra Details:
- Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5',-CCTTTGATC-3', in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small inTine.
- Shipping Conditions:
- Blue Ice