Recombinant TGF beta 1 Monoclonal Antibody

Size

£178.20

Was £198.00

SKU:: E-AB-81441
Additional Names:: CED,LAP,TGF beta 1,TGFB
Application:: WB
Concentration:: 300 ug/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% stabilizer and 0.05% protective protein.
Immunogen:: Recombinant protein of mouse TGF beta 1
Clone:: R08-8B7
Uniprot:: P04202
Synonyms:: TGF-beta;TGF-beta1;Tgfb;Tgfb-1;TGFbeta;TGFbeta1;transforming growth factor beta-1 proprotein
Extra Details:: TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease (CED) which known as progressive diaphyseal dysplasia 1 (DPD1).