E-AB-70388
CASP3 Polyclonal Antibody
Size
£178.20
Was £198.00
- SKU:
- E-AB-70388
- Additional Names:
- A830040C14Rik,Apopain,CASP-3,CASP3,CC3,CPP-32,CPP32,CPP32B,Casp3a,Caspase 3,Caspase-3 subunit p12,Cysteine p,apoptosis-related cysteine peptidase,apoptosis-related cysteine protease,apoptosis-related cysteine protease a
- Application:
- IHC
- Concentration:
- 500 ug/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Immunogen:
- KLH conjugated Synthetic peptide corresponding to Mouse caspase3
- Uniprot:
- P42574, P55213, P70677
- Synonyms:
- A830040C14Rik;AC-;AC-3;apopain;Casp;CASP-3;caspase 3, apoptosis related cysteine protease;Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease);caspase 3, apoptosis-related cysteine peptidase;caspase 3, apoptosis-related cysteine protease;caspase-3;CC3;CPP;CPP-32;CPP32;CPP32-beta;CPP32B;CPP32beta;cysteine protease CPP32;cysteine protease p32-beta;IRP;Lice;mld;mldy;PARP cleavage protease;procaspase3;protein Yama;SCA-1;SREBP cleavage activity 1;Ya;Yama
- Extra Details:
- Caspases, a family of endoproteases, are critical players in cell regulatory networks controlling inflammation and cell death. Initiator caspases (caspase-2, -8, -9, -10, -11, and -12) cleave and activate downstream effector caspases (caspase-3, -6, and -7), which in turn execute apoptosis by cleaving targeted cellular proteins. Caspase 3 (also named CPP32, SCA-1, and Apopain) proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at the beginning of apoptosis. Caspase 3 plays a key role in the activation of sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase 3 can also form heterocomplex with other proteins and performs MW of 50-70 kDa. This antibody can recognize p17, p19 and p32 of Caspase 3.
- Shipping Conditions:
- Blue Ice