E-AB-70368
SIRT1 Polyclonal Antibody
Size
£178.20
Was £198.00
- SKU:
- E-AB-70368
- Additional Names:
- 75SirT1,HST2,NAD dependent deacetylase sirtuin 1,NAD dependent protein deacetylase sirtuin 1,OTTHUMP00000198111,OTTHUMP00000198112,Regulatory protein SIR2 homolog 1,S. cerevisiae,S.cer,SIR1,SIR2,SIR2 like 1,SIR2 like protein 1,hSIR2,hSIRT1,homolog of
- Application:
- IHC
- Concentration:
- 1.2 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Immunogen:
- Recombinant protein corresponding to Mouse SIRT1
- Uniprot:
- Q923E4
- Synonyms:
- AA673258;NAD-dependent protein deacetylase sirtuin-1;NAD-dependent protein deacylase sirtuin-1;regulatory protein SIR2 homolog 1;S;Si;Sir2;SIR2-like protein 1;Sir2a;Sir2alpha;SIR2L1;sirtuin 1 ((silent mating type information regulation 2, homolog) 1
- Extra Details:
- SIRT1,also named as SIR2L1,contains a deacetylase sirtuin-type domain and belongs to the sirtuin family. It regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. SIRT1 in particular initiates several signalling events relevant to cardioprotection,including: activation of endothelial nitric oxide synthase,insulin receptor signalling,and autophagy. In addition SIRT1 activation elicits resistance to oxidative stress via regulation of transcription factors and co-activators such as FOXO,Hif-2a,and NF-kB. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53,specifically at Lysine 382.
- Shipping Conditions:
- Blue Ice