E-AB-70331
RBFOX3 Polyclonal Antibody
Size
£178.20
Was £198.00
- SKU:
- E-AB-70331
- Additional Names:
- FLJ56884,FLJ58356,FOX3NeuN,Fox-1 homolog C,Fox3,HRNBP3,NEUN,RFOX3,RNA binding protein,RNA binding protein fox-1 homolog 3,Rbfox3,fox 1 homolog (C. elegans) 3,fox1 homolog C,hexaribonucleotide binding protein 3,neuronal nuclei
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Immunogen:
- Recombinant protein corresponding to Mouse NEUN
- Uniprot:
- A6NFN3, Q8BIF2
- Synonyms:
- fox-1 homolog C;Fox-3;FOX3;hexaribonucleotide binding protein 3;Hexaribonucleotide-binding protein 3;Hrn;Hrnbp3;Ne;NeuN;neuN antigen;Neuna60;neuronal nuclear antigen A60;neuronal nuclei antigen;RNA binding protein fox-1 homolog 3;RNA binding protein, fox-1 homolog 3
- Extra Details:
- Immunoprecipitation and mass spectrometry of the two major NeuN species at 45-50 kDa identified both as the RNA binding protein Rbfox3 (a member of the Fox family of alternative splicing factors), confirming and extending the identification of the 45 kDa band as Rbfox3. Mapping of the anti-NeuN reactive epitopes in both R3hdm2 and Rbfox3 reveals a common proline- and glutamine-rich domain that lies at the N-terminus of the Rbfox3 protein. Nuclear Rbfox3 isoforms can also enhance the inclusion of cryptic exons in the Rbfox2 mRNA, resulting in nonsense-mediated decay of the message, thereby contributing to the negative regulation of Rbfox2 by Rbfox3 through a novel mechanism.
- Shipping Conditions:
- Blue Ice