E-AB-70329
Laminin beta1 Polyclonal Antibody
Size
£178.20
Was £198.00
- SKU:
- E-AB-70329
- Additional Names:
- CLM,Cutis laxa with marfanoid phenotype,LAM B1,LAMB 1,LAMB1,La,Laminin B1,Laminin B1 chain,Laminin beta 1 chain,Laminin beta 1 chain precursor,Laminin beta1,Laminin subunit beta 1,Laminin subunit beta-1,Laminin-1 subunit beta,Laminin-10 subunit beta
- Application:
- WB
- Concentration:
- 1.2 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Immunogen:
- Recombinant protein corresponding to Mouse Laminin B Beta1
- Uniprot:
- P02469, P07942
- Synonyms:
- C77966;C80098;C81607;CLM;D130003D08Rik;Lamb;Lamb-1;Lamb1-1;laminin B1 chain;laminin B1 subunit 1;laminin subunit beta-1;laminin-1 subunit beta;laminin-10 subunit beta;laminin-111;laminin-12 subunit beta;laminin-2 subunit beta;laminin-6 subunit beta;laminin-8 subunit beta;laminin, beta 1;LIS5
- Extra Details:
- Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.
- Shipping Conditions:
- Blue Ice