E-AB-70313
N/H/K-Ras Polyclonal Antibody
Size
£178.20
Was £198.00
- SKU:
- E-AB-70313
- Additional Names:
- GTPase HRas,GTPase KRas,GTPase NRas,H-Ras-1,HRAS,HRAS1,Ha-Ras,K-Ras 2,KRAS,KRAS2,Ki-Ras,NRAS,RASK2,Transforming protein N-Ras,Transforming protein p21,c-H-ras,c-K-ras,c-Ki-ras,p21ras
- Application:
- WB
- Concentration:
- 0.58 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Immunogen:
- KLH conjugated Synthetic peptide corresponding to Mouse K-Ras
- Uniprot:
- P08644, P20171, P32883, Q61411
- Synonyms:
- AI929937;c-H-;c-H-ras;c-Ha-ras;c-Ha-ras p21 protein;c-Ha-ras transgene;c-K-ras;c-K-ras2 protein;c-Ki-ras;c-Kirsten-ras proto-oncogene;c-r;c-rasHa;GTPase HRas;GTPase KRas;H-;H-ras;H-ras 1 protein;H-Ras-1;Ha;Ha-ras;Harv;Harvey ras1 protein;Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog;Harvey rat sarcoma virus oncogene;Harvey rat sarcoma virus oncogene 1;Harvey-ras;Hr;Hra;Hras-1;Hras1;K-;K-Ras;K-Ras 2;Ki;Ki-ras;Kirsten rat sarcoma oncogene 2, expressed;Kirsten rat sarcoma viral oncogene homolog;Kirsten rat sarcoma viral oncogene homologue 2 (active);Kr;Kra;Kras-2;Kras2;p21;p21 protein;p21B;p21ras;ras;transforming protein P21;v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
- Extra Details:
- NRAS an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. HRAS belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. KRAS, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma.
- Shipping Conditions:
- Blue Ice