E-AB-70311
PD-1/CD279 Polyclonal Antibody
Size
£178.20
Was £198.00
- SKU:
- E-AB-70311
- Additional Names:
- CD279,CD279 antigen,PD 1,PD-1,PD1,PDCD 1,PDCD1,Programmed cell death 1,Programmed cell death 1 protein,Programmed cell death protein 1,Protein PD 1,Protein PD-1,SLEB2,Systemic lupus erythematosus susceptibility 2,hPD 1,hPD l,hPD-1,hSLE1
- Application:
- WB
- Concentration:
- 0.75 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Immunogen:
- KLH conjugated Synthetic peptide corresponding to Mouse PD-1
- Uniprot:
- Q02242, Q15116
- Synonyms:
- CD279;hPD-1;hPD-l;hSLE1;Ly101;mPD-1;PD-;PD-1;PD1;Pdc;Pdc1;programmed cell death 1 protein;programmed cell death protein 1;protein PD-1;SLEB2;systemic lupus erythematosus susceptibility 2
- Extra Details:
- Programmed cell death 1 (PD-1,also known as CD279) is an immunoinhibitory receptor that belongs to the CD28/CTLA-4 subfamily of the Ig superfamily. It is a 288 amino acid (aa) type I transmembrane protein composed of one Ig superfamily domain,a stalk,a transmembrane domain,and an intracellular domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) as well as an immunoreceptor tyrosine-based switch motif (ITSM) . PD-1 is expressed during thymic development and is induced in a variety of hematopoietic cells in the periphery by antigen receptor signaling and cytokines . Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation,cytokine production,and cytolytic function . It is critical for the regulation of T cell function during immunity and tolerance. Blockade of PD-1 can overcome immune resistance and also has been shown to have antitumor activity . The calculated molecular weight of PD-1 is 32 kDa. It has been reported that PD-1 is heavily glycosylated and migrates with an apparent molecular mass of 47-55 kDa on SDS-PAGE .
- Shipping Conditions:
- Blue Ice