E-AB-70304
MTOR Polyclonal Antibody
Size
£178.20
Was £198.00
- SKU:
- E-AB-70304
- Additional Names:
- FK506 binding protein 12 rapamycin associated protein 1,FK506 binding protein 12 rapamycin associated protein 2,FK506 binding protein 12 rapamycin complex associated protein 1,FK506-bindi,dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1)
- Application:
- WB
- Concentration:
- 0.8 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Immunogen:
- Recombinant protein corresponding to Mouse mTOR
- Uniprot:
- P42345, P42346, Q9JLN9
- Synonyms:
- 2610315D21Rik;AI327068;angiopoietin-like factor CDT6;FK506 binding protein 12-rapamycin associated protein 1;FK506 binding protein 12-rapamycin associated protein 2;FK506-binding protein 12-rapamycin complex-associated protein 1;FKBP-rapamycin associated protein;FKBP-rapamycin associated protein (FRAP);FKBP12-rapamycin complex-associated protein;FKBP12-rapamycin complex-associated protein 1;fl;flat;Fr;FRAP;FRAP1;FRAP2;mammalian target of rapamycin;Mechanistic target of rapamycin;mechanistic target of rapamycin (serine/threonine kinase);RA;RAF;RAFT1;rapamycin and FKBP12 target 1;rapamycin and FKBP12 target-1 protein;rapamycin associated protein FRAP2;rapamycin target protein 1;RAPT1;serine/threonine-protein kinase mTOR;SKS
- Extra Details:
- MTOR, also named as FRAP1, FRAP, FRAP2 and RAPT1, belongs to the PI3/PI4-kinase family. MTOR is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. MTOR is Kinase subunit of both mTORC1 and mTORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. The antibody is specific to MTOR.
- Shipping Conditions:
- Blue Ice