CASP1 Polyclonal Antibody

Size

£178.20

Was £198.00

SKU:: E-AB-70300
Additional Names:: CASP-1,CASP1,Caspase 1,Caspase-1 subunit p10,ICE,IL-1 beta-converting enzyme,IL-1BC,IL1 beta converting enzyme,IL1B convertase,Interleukin 1 beta convertase,Interleukin 1B converting enzyme,Interleukin-1 beta convertase,Interleukin-1 beta-converting
Application:: IHC, WB
Concentration:: 1.2 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
Immunogen:: Recombinant protein corresponding to Mouse Caspase1
Uniprot:: P29452, P29466, P43527
Synonyms:: Casp;CASP-1;CASP1 nirs variant 1;caspase 1, apoptosis-related cysteine peptidase;caspase-1;caspase-1 isoform alpha;IC;ICE;IL-1 beta-converting enzyme;IL-1B converting enzyme;IL-1BC;Il1;IL1B-convertase;IL1BC;interleukin 1-B converting enzyme;interleukin 1, beta, convertase;interleukin-1 beta convertase;interleukin-1 beta-converting enzyme;P45
Extra Details:: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

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