PKM Polyclonal Antibody

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£178.20

Was £198.00

SKU:: E-AB-70274
Additional Names:: CTHBP,Cytosolic thyroid hormone binding protein,Cytosolic thyroid hormone-binding protein,KPYM,MGC3932,OIP 3,OIP-3,OIP3,OPA interacting protein 3,Opa-interacting protein 3,PK,PK muscle type,PK2,PK3,PKM,PKM2,Pyruvat,Pyruvate kinase 2/3,muscle type,p58,pykm
Application:: WB
Concentration:: 440 ug/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
Immunogen:: Recombinant protein corresponding to Mouse PKM2
Uniprot:: P11980, P14618, P52480
Synonyms:: AA414905;AL024370;AL024424;CTHBP;cytosolic thyroid hormone-binding protein;epididymis secretory protein Li 30;HEL-S-30;M2 pyruvate kinase;OIP3;OPA-interacting protein 3;p58;Pk;Pk-;Pk-2;Pk-3;PK, muscle type;PK3;PKM12;PKM2;pyruvate kinase 2/3;pyruvate kinase 3;pyruvate kinase isozymes M1/M2;pyruvate kinase muscle isozyme;pyruvate kinase PKM;pyruvate kinase, muscle;TCB;THBP1;thyroid hormone-binding protein 1;thyroid hormone-binding protein, cytosolic;tumor M2-PK
Extra Details:: PKM2,also named as OIP3,PK2,PK3,PKM,p58,THBP1,CTHBP and Tumor M2-PK,belongs to the pyruvate kinase family. It is glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP,generating ATP. It stimulates POU5F1-mediated transcriptional activation. PKM2 plays a general role in caspase independent cell death of tumor cells. The activity of the M2 isoform (but not the M1 isoform) can be inhibited by tyrosine kinase signalling in tumourcells.The primary pyruvate kinase isoform before tumour development is PK-M1, however,the primary isoform from four independent tumours is PK-M2. PKM2,Pyruvate kinase isozymes M1/M2,has 2 isoforms .The immunogen of this antibody is M2 isoform,also called PKM2.

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