E-AB-70200
INPP5D Polyclonal Antibody
Size
£178.20
Was £198.00
- SKU:
- E-AB-70200
- Additional Names:
- 4,5-trisphosphate 5-phosphatase 1,INPP5D,Inositol polyphosphate 5 phosphatase,Inositol polyphosphate 5 phosphatase 145kDa,Inositol polyphosphate 5 phosphatase of 145kDa,Inositol polyphosphate-5-phosphatase of 145 kDa,MGC104855,MGC142140,MGC142142,hp51CN,p
- Application:
- IHC
- Concentration:
- 430 ug/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Immunogen:
- KLH conjugated Synthetic peptide corresponding to Mouse SHIP1
- Uniprot:
- P97573, Q9ES52
- Synonyms:
- Inositol polyphosphate-5-phosphatase of 145 kDa;inositol polyphosphate-5-phosphatase, 145 kDa;p150Ship;phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1;phosphatidylinositol-4,5-bisphosphate 5-phosphatase;S;s-;s-SHIP;SH;SH2 domain-containing inositol 5'-phosphatase 1;SH2 domain-containing inositol phosphatase 1;SH2-containing inositol phosphatase SHIP;SHI;SHIP;SHIP-1;SHIP1;SIP-145;Src homology 2 domain-containing inositol-5-phosphatase
- Extra Details:
- This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.
- Shipping Conditions:
- Blue Ice