E-AB-70124
ROCK1 Polyclonal Antibody
Size
£178.20
Was £198.00
- SKU:
- E-AB-70124
- Additional Names:
- MGC131603,MGC43611,PRO0435,Renal carcinoma antigen NY REN 35,Renal carcinoma antigen NY-R,coiled-coil-containing protein kinase 1,coiled-coil-containing protein kinase I,p160 ROCK-1,p160 ROCK1,p160 Rhoassociated coiled coil-forming protein kinase,p160ROCK
- Application:
- IHC
- Concentration:
- 300 ug/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Immunogen:
- KLH conjugated Synthetic peptide corresponding to Mouse Rock1
- Uniprot:
- P70335, Q63644
- Synonyms:
- 1110055K06Rik;liver regeneration-related protein LRRG199;p150 RhoA-binding kinase ROK beta;p160 ROCK-1;p160ROCK;Rho-associated coiled-coil forming kinase 1;Rho-associated kinase beta;rho-associated protein kinase 1;rho-associated, coiled-coil-containing protein kinase 1;rho-associated, coiled-coil-containing protein kinase I;Roc;Rock-I
- Extra Details:
- This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
- Shipping Conditions:
- Blue Ice