E-AB-70089
IkB alpha Polyclonal Antibody
Size
£178.20
Was £198.00
- SKU:
- E-AB-70089
- Additional Names:
- I kappa B alpha,I-kappa-B-alpha,IKBA,IKBalpha,IkB-alpha,IkappaBalpha,MAD 3,MAD3,Major histocompatibility complex enhancer-binding protein MAD3,NF kappa B inhibitor alpha,NF-kappa-B inhibitor alpha,NFKBI,NFKBIA,Nuclear factor of kappa light chain gene
- Application:
- IHC
- Concentration:
- 1.3 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Immunogen:
- KLH conjugated Synthetic peptide corresponding to Mouse IKBA Alpha
- Uniprot:
- P25963, Q9Z1E3
- Synonyms:
- AI462015;EDAID2;I-kappa-B-alpha;I-kappaBalpha;I(Kappa)B(alpha);IkappaBalpha;ikB-alpha;IKBA;MAD-3;major histocompatibility complex enhancer-binding protein MAD3;NF-kappa-B inhibitor alpha;Nfk;NFKBI;nuclear factor of kappa light chain gene enhancer in B-cells;nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha;nuclear factor of kappa light polyp gene enhancer in B-cell 1;nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
- Extra Details:
- Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor,alpha (NFKBIA,synonyms: IKBA,MAD-3,NFKBI). NFKB1 or NFKB2 is bound to REL,RELA ,or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB),which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA,or IKBKB) marks them for destruction via the ubiquitination pathway,thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime.
- Shipping Conditions:
- Blue Ice