E-AB-70029
JUN Polyclonal Antibody
Size
£178.20
Was £198.00
- SKU:
- E-AB-70029
- Additional Names:
- AP 1,AP1,Activator protein 1,Enhancer Binding Protein AP1,JUN,JUN protein,JUNC,Jun Activation Domain Binding Protein,Jun oncogene,Jun proto oncogene,Oncogene JUN,Proto oncogene c jun,Proto oncogene cJun,Proto-oncogene c-jun,Transcription Fact,cJun,p39
- Application:
- IHC
- Concentration:
- 1.15 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer, 1% protein protectant and 50% glycerol.
- Immunogen:
- KLH conjugated Synthetic peptide corresponding to Mouse c- JUN
- Uniprot:
- P05412, P05627, P17325
- Synonyms:
- activator protein 1;AH119;AP-1;AP1;Avian sarcoma virus 17 (v-jun) oncogene homolog;c-ju;c-Jun;cJUN;enhancer-binding protein AP1;immediate early;jun A;Jun activation domain binding protein;jun oncogene;Junc;p39;proto-oncogene c-Jun;proto-oncogene cJun;transcription factor AP-1;v-jun avian sarcoma virus 17 oncogene homolog;v-jun sarcoma virus 17 oncogene homolog
- Extra Details:
- JUN is also named as c-Jun and AP1,belongs to the bZIP family and Jun subfamily. JUN,the most extensively studied protein of the activator protein-1 (AP-1) complex,is involved in numerous cell activities,such as proliferation,apoptosis,survival,tumorigenesis and tissue morphogenesis. JUN is a transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. It promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. JUN is a basic leucine zipper (bZIP) transcription factor that acts as homo- or heterodimer,binding to DNA and regulating gene transcription. In additon,extracellular signals can induce post-translational modifications of JUN,resulting in altered transcriptional activity and target gene expression. More over,it has uncovered multiple layers of a complex regulatory scheme in which JUN is able to crosstalk,amplify and integrate different signals for tissue development and disease. Jun is predominantly nuclear,ubiquitinated Jun colocalizes with lysosomal proteins.
- Shipping Conditions:
- Blue Ice