E-AB-68341
NCF4 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-68341
- Additional Names:
- CGD3,NCF,NCF4,P40PHOX,SH3PXD4
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human NCF4
- Uniprot:
- Q15080
- Synonyms:
- CGD3;NCF;NCF-4;neutrophil cytosol factor 4;neutrophil cytosolic factor 4, 40kDa;neutrophil NADPH oxidase factor 4;p40-phox;P40PHOX;SH3 and PX domain-containing protein 4;SH3PXD4
- Extra Details:
- The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
- Shipping Conditions:
- Blue Ice