E-AB-68339
CBLB Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-68339
- Additional Names:
- CBLB,Cbl-b,Nbla00127,RNF56
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human CBLB
- Uniprot:
- Q13191
- Synonyms:
- Cas-Br-M (murine) ecotropic retroviral transforming sequence b;casitas B-lineage lymphoma proto-oncogene b;Cbl proto-oncogene B, E3 ubiquitin protein ligase;Cbl proto-oncogene, E3 ubiquitin protein ligase B;Cbl-b;E3 ubiquitin-protein ligase CBL-B;Nbla00127;RING finger protein 56;RING-type E3 ubiquitin transferase CBL-B;RNF56;SH3-binding protein CBL-B;signal transduction protein CBL-B
- Extra Details:
- E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor, BCR (B-cell receptor and FCER1 (high affinity immunoglobulin epsilon receptor signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA signaling pathway via ubiquitination and internalization of PDGFRA (By similarity.
- Shipping Conditions:
- Blue Ice