B7-H3/CD276 Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-68332
Additional Names:: 4Ig-B7-H3,B7-H3,B7H3,B7RP-2,CD276
Application:: IHC, WB
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: A synthetic peptide of human B7-H3/CD276
Uniprot:: Q5ZPR3
Synonyms:: 4Ig-B7-H3;B7 homolog 3;B7-H3;B7H3;B7RP-2;CD276 antigen;costimulatory molecule
Extra Details:: The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3&apos, UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.