E-AB-68304
PSMC5 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-68304
- Additional Names:
- ATPase 5,PSMC5,S8,SUG-1,SUG1,TBP10,TRIP1,p45,p45/SUG
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human PSMC5
- Uniprot:
- P62195
- Synonyms:
- 26S protease regulatory subunit 8;26S proteasome AAA-ATPase subunit RPT6;26S proteasome regulatory subunit 8;MSUG1 protein;p45;p45/SUG;proteasome (prosome, macropain) 26S subunit, ATPase, 5;proteasome 26S ATPase subunit 5;Proteasome 26S subunit ATPase 5;proteasome subunit p45;RPT6;S8;SUG-1;SUG1;Tat-binding protein homolog 10;TBP10;testicular tissue protein Li 149;thyroid hormone receptor-interacting protein 1;thyroid receptor interactor 1;TRIP1
- Extra Details:
- The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene.
- Shipping Conditions:
- Blue Ice