E-AB-67973
RSPO1 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-67973
- Additional Names:
- CRISTIN3,RSPO,RSPO1
- Application:
- IHC
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human RSPO1 (NP_001033722.1).
- Uniprot:
- Q2MKA7
- Synonyms:
- CRISTIN3;R-spondin homolog;R-spondin-1;roof plate-specific spondin-1;RSPO
- Extra Details:
- This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants.
- Shipping Conditions:
- Blue Ice