E-AB-67927
PDE6A Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-67927
- Additional Names:
- CGPR-A,PDE6A,PDEA,RP43
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human PDE6A (NP_000431.2).
- Uniprot:
- P16499
- Synonyms:
- cGMP phosphodiesterase alpha subunit;CGPR-A;GMP-PDE alpha;PDE V-B1;PDEA;phosphodiesterase 6A, cGMP-specific, rod, alpha;retinitis pigmentosa type 43;rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha;rod photoreceptor cGMP phosphodiesterase alpha subunit;RP43
- Extra Details:
- This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
- Shipping Conditions:
- Blue Ice