BAP1 Polyclonal Antibody

Size

£211.50

Was £235.00

SKU:: E-AB-67774
Additional Names:: BAP1,HUCEP-13,UCHL2,hucep-6
Application:: IHC, WB, IF
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human BAP1 (NP_004647.1).
Uniprot:: Q92560
Synonyms:: BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase);BRCA1-associated protein 1;cerebral protein 6;cerebral protein-13;HUCEP-13;hucep-6;ubiquitin carboxyl-terminal hydrolase BAP1;UCHL2
Extra Details:: This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.