ALOX5 Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-67417
Additional Names:: 5-LO,5-LOX,5LPG,ALOX5,LOG5
Application:: IHC, IF
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human ALOX5 (NP_000689.1).
Uniprot:: P09917
Synonyms:: 5-LO;5-LOX;5LPG;arachidonic acid 5-lipoxygenase;leukotriene A4 synthase;LOG5;LOX-5;polyunsaturated fatty acid 5-lipoxygenase
Extra Details:: This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.