E-AB-67409
INS Polyclonal Antibody
Size
£211.50
Was £235.00
- SKU:
- E-AB-67409
- Additional Names:
- IDDM,IDDM1,IDDM2,ILPR,INS,IRDN,Insulin,MODY10,insulin
- Application:
- IHC, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human INS (NP_000198.1).
- Uniprot:
- P01308
- Synonyms:
- IDDM;IDDM1;IDDM2;ILPR;insulin;IRDN;MODY10;PNDM4;preproinsulin;proinsulin
- Extra Details:
- After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
- Shipping Conditions:
- Blue Ice