E-AB-67345
DNA polymerase eta Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-67345
- Additional Names:
- POLH,RAD30,RAD30A,XP-V,XPV
- Application:
- WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human DNA polymerase eta (NP_006493.1).
- Uniprot:
- Q9Y253
- Synonyms:
- DNA polymerase eta;polymerase (DNA directed), eta;polymerase (DNA) eta;RAD30;RAD30 homolog A;RAD30A;xeroderma pigmentosum variant type protein;XP-V;XPV
- Extra Details:
- This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA, when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.
- Shipping Conditions:
- Blue Ice