E-AB-67299
Pan-AKT Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-67299
- Additional Names:
- AKT1/AKT2/AKT3
- Application:
- IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- A synthetic peptide of human AKT1/AKT2/AKT3
- Uniprot:
- P31749, P31751, Q9Y243
- Synonyms:
- AKT;AKT1m;HIHGHH;MPPH;MPPH2;murine thymoma viral (v-akt) homolog-2;PKB;PKB alpha;PKB beta;PKB gamma;PKB-ALPHA;PKB-GAMMA;PKBB;PKBBETA;PKBG;PRKBA;PRKBB;PRKBG;protein kinase Akt-2;Protein kinase Akt-3;Protein kinase B;protein kinase B alpha;protein kinase B beta;Protein kinase B gamma;proto-oncogene c-Akt;putative v-akt murine thymoma viral oncoprotein 2;RAC;rac protein kinase alpha;rac protein kinase beta;RAC-ALPHA;RAC-alpha serine/threonine-protein kinase;RAC-BETA;RAC-beta serine/threonine-protein kinase;RAC-gamma;RAC-gamma serine/threonine protein kinase;RAC-gamma serine/threonine-protein kinase;RAC-PK-alpha;RAC-PK-beta;RAC-PK-gamma;serine-threonine protein kinase;STK-2;v-akt murine thymoma viral oncogene homolog 1;v-akt murine thymoma viral oncogene homolog 2;v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma);v-akt murine thymoma viral oncogene-like protein 1
- Extra Details:
- The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene./This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways.
- Shipping Conditions:
- Blue Ice