CD82 Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-67224
Additional Names:: 4F9,C33,CD82,GR15,IA4,KAI1,R2,SAR2,ST6,TSPAN27
Application:: IHC
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: A synthetic peptide of human CD82 (NP_002222.1).
Uniprot:: P27701
Synonyms:: 4F9;C33;C33 antigen;CD82 antigen;GR15;IA4;inducible membrane protein R2;KAI1;kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4));metastasis suppressor Kangai-1;R2;SAR2;ST6;Suppressor of tumorigenicity 6 protein;tetraspanin-27;tspan-27;TSPAN27
Extra Details:: This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.