E-AB-67096
PRKAA1/PRKAA2 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-67096
- Additional Names:
- AMPKa1/AMPKa2
- Application:
- IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human PRKAA1/PRKAA2.
- Uniprot:
- P54646, Q13131
- Synonyms:
- 5'-AMP-activated protein kinase catalytic subunit alpha-1;5'-AMP-activated protein kinase catalytic subunit alpha-2;5'-AMP-activated protein kinase, catalytic alpha-1 chain;5'-AMP-activated protein kinase, catalytic alpha-2 chain;ACACA kinase;acetyl-CoA carboxylase kinase;AMP -activate kinase alpha 1 subunit;AMP-activated protein kinase alpha-2 subunit variant 2;AMP-activated protein kinase alpha-2 subunit variant 3;AMP-activated protein kinase, catalytic, alpha-1;AMPK;AMPK alpha 1;AMPK alpha 2;AMPK subunit alpha-1;AMPK subunit alpha-2;AMPK-alpha-2 chain;AMPK, alpha, 1;AMPK2;AMPKa1;AMPKa2;head maturation protease;HMGCR kinase;HWC90_gp38;hydroxymethylglutaryl-CoA reductase kinase;laban61_gp038;PRKAA;protein kinase, AMP-activated, alpha 1 catalytic subunit;protein kinase, AMP-activated, alpha 2 catalytic subunit;tau-protein kinase PRKAA1
- Extra Details:
- The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed./The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
- Shipping Conditions:
- Blue Ice