TLR5 Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-67080
Additional Names:: MELIOS,SLE1,SLEB1,TIL3,TLR5
Application:: IHC, WB
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human TLR5 (NP_003259.2).
Uniprot:: O60602
Synonyms:: MELIOS;SLE1;SLEB1;systemic lupus erythematosus susceptibility 1;TIL3;toll-like receptor 5;toll/interleukin-1 receptor-like protein 3
Extra Details:: This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.