BRK1 Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-67071
Additional Names:: BRK1,C3orf10,HSPC300,MDS027,hHBrk1
Application:: IHC, IF
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human BRK1 (NP_060932.2).
Uniprot:: Q8WUW1
Synonyms:: BRICK1, SCAR/WAVE actin nucleating complex subunit;C3orf10;haematopoietic stem/progenitor cell protein 300;hHBrk1;HSPC300;MDS027;protein BRICK1
Extra Details:: HSPC300 (hematopoietic stem cell protein 300) is also known as probable protein BRICK1 or C3orf10 (chromosome 3 open reading frame 10) and is a 75 amino acid protein that is expressed as two isoforms and localizes to both the cytoplasm and the cytoskeleton. HSPC300 is thought to regulate cytoskeletal organization and Actin polymerization. Free HSPC300 exists as homotrimers prior to its incorporation into the WAVE complex. The WAVE complex includes five proteins, one of which is HSPC300, that regulate the ARC (Arp2/3 complex) which is responsible for Actin nucleation and is Rac 1-dependent. Because HSPC300 is a highly conserved subunit of the WAVE complex across many species, it is thought to have the same or similar functions in many different organisms.