E-AB-67031
Complement Factor B Polyclonal Antibody
Size
£211.50
Was £235.00
- SKU:
- E-AB-67031
- Additional Names:
- AHUS4,ARMD14,BF,BFD,CFAB,CFB,CFBD,FB,FBI12,GBG,H2-Bf,PBF2
- Application:
- IHC, WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- ABP:
- Not Sure -> Send to PM
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human Complement Factor B (NP_001701.2).
- Uniprot:
- P00751
- Synonyms:
- AHUS4;ARMD14;B-factor, properdin;BF;BFD;C3 proaccelerator;C3 proactivator;C3/C5 convertase;CFAB;CFBD;complement factor B;FB;FBI12;GBG;Glycine-rich beta glycoprotein;glycine-rich beta-glycoprotein;H2-Bf;PBF2;properdin factor B
- Extra Details:
- This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
- Shipping Conditions:
- Blue Ice