E-AB-66586
TAZ Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-66586
- Additional Names:
- AGMX1,AT,ATK,BPK,BTK,Bruton tyrosine kinase,IMD1,PSCTK1,TAZ,WWTR1,XLA
- Application:
- IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- A synthetic peptide of human TAZ (NP_056287.1).
- Uniprot:
- Q9GZV5
- Synonyms:
- TAZ;transcriptional co-activator with PDZ-binding motif;Transcriptional coactivator with PDZ-binding motif;WW domain-containing transcription regulator protein 1
- Extra Details:
- TAZ, also referred as WWTR1, is a transcriptional co-activator with a PDZ-binding motif that is regulated by its interaction with 14-3-3 protein. TAZ is expressed in many primary tumors, such as breast cancer, thyroid carcinoma, colorectal cancer, and glioma. TAZ has been reported to be one of the nuclear effectors of Hippo-related pathways that regulate organ size control, cancer stem cell (CSC) properties, and epithelial-mesenchymal transition (EMT). TAZ has been defined for its role in the nucleus, where it functions directly as a transcriptional regulator by interacting with several nuclear factors as Runx2/Cbfa1, NHERF-2, TEF-1, TBX5, PAX3, PAX8 and TTF-1.
- Shipping Conditions:
- Blue Ice