E-AB-66572
UNC13B Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-66572
- Additional Names:
- MUNC13,UNC13,UNC13B,Unc13h2
- Application:
- WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human UNC13B (NP_006368.3).
- Uniprot:
- O14795
- Synonyms:
- homolog of rat Munc13 (diacylglycerol-binding);MUNC13;munc13-2;protein unc-13 homolog B;unc-13-like;UNC13;Unc13h2
- Extra Details:
- This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.
- Shipping Conditions:
- Blue Ice