IMPDH2 Polyclonal Antibody

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£195.30

Was £217.00

SKU:: E-AB-66509
Additional Names:: IMPD2,IMPDH-II,IMPDH2
Application:: WB
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human IMPDH2 (NP_000875.2).
Uniprot:: P12268
Synonyms:: epididymis secretory sperm binding protein;IMP (inosine 5'-monophosphate) dehydrogenase 2;IMP (inosine monophosphate) dehydrogenase 2;IMP dehydrogenase II;IMP oxireductase 2;IMPD 2;IMPD2;IMPDH 2;IMPDH-II;inosine 5' phosphate dehydrogenase 2;inosine monophosphate dehydrogenase type II;inosine-5'-monophosphate dehydrogenase 2;inosine-5'-monophosphate dehydrogenase type II
Extra Details:: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.