TNFR1 Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-66479
Additional Names:: CD120a,FPF,TBP1,TNF-R,TNF-R-I,TNF-R55,TNFAR,TNFR1,TNFR55,TNFR60,TNFRSF1A,p55,p55-R,p60
Application:: IHC
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human TNFR1 (NP_001056.1).
Uniprot:: P19438
Synonyms:: CD120a;FPF;p55;p55-R;p60;TBP1;TNF-R;TNF-R-I;TNF-R1;TNF-R55;TNF-RI;TNFAR;TNFR-I;TNFR1;TNFR55;TNFR60;tumor necrosis factor binding protein 1;Tumor necrosis factor receptor 1;tumor necrosis factor receptor superfamily member 1A;tumor necrosis factor receptor type 1;Tumor necrosis factor receptor type I;tumor necrosis factor-alpha receptor
Extra Details:: This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients.

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