E-AB-66447
PRR5 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-66447
- Additional Names:
- FLJ20185k,PP610,PROTOR-1,PROTOR1,PRR5
- Application:
- IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human PRR5 (NP_851850.1).
- Uniprot:
- P85299
- Synonyms:
- FLJ20185k;PP610;proline rich 5 (renal);proline-rich protein 5;protein observed with Rictor-1;PROTOR-1;PROTOR1;Rho GTPase activating protein 8
- Extra Details:
- This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
- Shipping Conditions:
- Blue Ice