E-AB-66300
CISH Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-66300
- Additional Names:
- BACTS2,CIS,CIS-1,CISH,G18,SOCS
- Application:
- IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human CISH (NP_659508.1).
- Uniprot:
- Q9NSE2
- Synonyms:
- BACTS2;CIS;CIS-1;cytokine-inducible inhibitor of signaling type 1B;cytokine-inducible SH2-containing protein;G18;Protein G18;SOCS;suppressor of cytokine signaling
- Extra Details:
- The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
- Shipping Conditions:
- Blue Ice