E-AB-66035
UMPS Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-66035
- Additional Names:
- OPRT,UMPS
- Application:
- IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human UMPS (NP_000364.1).
- Uniprot:
- P11172
- Synonyms:
- OMPdecase;OPRT;OPRTase;orotate phosphoribosyltransferase;orotidine 5'-phosphate decarboxylase;UMP synthase;uridine 5'-monophosphate synthase
- Extra Details:
- This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants.
- Shipping Conditions:
- Blue Ice