RAD51C Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-65915
Additional Names:: BROVCA3,FANCO,R51H3,RAD51C,RAD51L2
Application:: IF
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human RAD51C (NP_002867.1).
Uniprot:: O43502
Synonyms:: BROVCA3;DNA repair protein RAD51 homolog 3;FANCO;R51H3;RAD51 homolog C;RAD51-like protein 2;RAD51L2;yeast RAD51 homolog 3
Extra Details:: This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants.