E-AB-65790
HSD17B1 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-65790
- Additional Names:
- 17-beta-HSD,20-alpha-HSD,E2DH,EDH17B2,EDHB17,HSD17,HSD17B1,SDR28C1
- Application:
- IHC, IF
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human HSD17B1 (NP_000404.2).
- Uniprot:
- P14061
- Synonyms:
- 17-beta-HSD;17-beta-HSD 1;17-beta-hydroxysteroid dehydrogenase type 1;20 alpha-hydroxysteroid dehydrogenase;20-alpha-HSD;E2DH;EDH17B2;EDHB17;estradiol 17-beta-dehydrogenase 1;HSD17;placental 17-beta-hydroxysteroid dehydrogenase;SDR28C1;short chain dehydrogenase/reductase family 28C member 1;short chain dehydrogenase/reductase family 28CE, member 1
- Extra Details:
- Hydroxysteroid (17-beta) dehydrogenase 1 catalyzes the final step in the formation of estradiol and testosterone from estrone and androstenedione, respectively. Ovarian granulosa cells and breast tissue both express HSD17B1. Other tissues that express HSD17B1 include testis, placenta, uterus, prostate and adipose tissue. HSD17B1 functions as a homodimer and prefers NADP(H) over NAD(H) for oxidation and reduction. The gene encoding human HSD17B1 maps to chromosome 17q12-q21. The importance of HSD17B1 to estradiol production suggests the specific inhibition of HSD17B1 may aid in breast cancer therapy.
- Shipping Conditions:
- Blue Ice