EGLN1 Polyclonal Antibody

Size

£195.30

Was £217.00

SKU:: E-AB-65402
Additional Names:: C1orf12,ECYT3,EGLN1,HALAH,HIF-PH2,HIFPH2,HPH-2,HPH2,PHD2,SM20,ZMYND6
Application:: IF
Concentration:: 1 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant fusion protein of human EGLN1 (NP_071334.1).
Uniprot:: Q9GZT9
Synonyms:: C1orf12;ECYT3;egl nine homolog 1;egl nine-like protein 1;HALAH;HIF-PH2;HIF-prolyl hydroxylase 2;HIFPH2;HPH-2;HPH2;hypoxia-inducible factor prolyl hydroxylase 2;PHD2;prolyl hydroxylase domain-containing protein 2;SM-20;SM20;zinc finger MYND domain-containing protein 6;ZMYND6
Extra Details:: The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).