E-AB-65198
SIM2 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-65198
- Additional Names:
- HMC13F06,HMC29C01,SIM,SIM2,bHLHe15
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human SIM2 (NP_033664.2).
- Uniprot:
- Q14190
- Synonyms:
- bHLHe15;class E basic helix-loop-helix protein 15;HMC13F06;HMC29C01;SIM;single-minded family bHLH transcription factor 2;single-minded homolog 2;transcription factor SIM2
- Extra Details:
- This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants.
- Shipping Conditions:
- Blue Ice