E-AB-65122
BAG3 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-65122
- Additional Names:
- BAG-3,BAG3,BIS,CAIR-1,MFM6
- Application:
- IHC
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human BAG3 (NP_004272.2).
- Uniprot:
- O95817
- Synonyms:
- BAG family molecular chaperone regulator 3;BAG-3;Bcl-2-associated athanogene 3;bcl-2-binding protein Bis;Bcl-2-binding protein BIS transcript 2;BCL2 associated athanogene 3;BCL2-binding athanogene 3;BIS;CAIR-1;docking protein CAIR-1;MFM6
- Extra Details:
- BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
- Shipping Conditions:
- Blue Ice