E-AB-65050
F13A1 Polyclonal Antibody
Size
£195.30
Was £217.00
- SKU:
- E-AB-65050
- Additional Names:
- F13A,F13A1
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human F13A1 (NP_000120.2).
- Uniprot:
- P00488
- Synonyms:
- bA525O21.1 (coagulation factor XIII, A1 polypeptide);coagulation factor XIII A chain;coagulation factor XIII, A polypeptide;coagulation factor XIII, A1 polypeptide;coagulation factor XIIIa;F13A;factor XIIIa;fibrin stabilizing factor, A subunit;fibrinoligase;FSF, A subunit;protein-glutamine gamma-glutamyltransferase A chain;TGase;transglutaminase A chain;transglutaminase. plasma
- Extra Details:
- This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
- Shipping Conditions:
- Blue Ice